
WHO WE ARE
Tetratherix (formerly Trimph) is an Australian biomedical company that has developed TetraMatrix, a novel class of regenerative scaffolds.
TetraMatrix is a water based solution that forms an adhesive hydrogel once administered to the body. The product is fully synthetic, biocompatible and resorbable. TetraMatrix has been clinically tested, demonstrating both safety and efficacy.
Tetratherix has a robust Intellectual Property portfolio including granted patents in the USA and Europe as well as multiple international patent applications.
After 5 years in development at the University of Sydney, Tetratherix was incorporated in 2015. The company’s Sydney based production facility is ISO13485:2016 certified.
Tetratherix is supported by both NSW and Federal government grants. Tetratherix is backed by Ryder Innovation Fund, a venture capital limited partnership specialising in medtech opportunities.
TECHNOLOGY

Injectable
TetraMatrix is an injectable, water based scaffold that can be administered to without the need for invasive surgery.

Temperature Responsive
At body temperature, TetraMatrix instantly forms an adhesive hydrogel to provide a synthetic extracellular matrix to support tissue repair.

Regenerative
TetraMatrix compliments the healing process by providing an optimised environment for cellular ingrowth and regeneration.

Resorbable
TetraMatrix resorbs to the body over time while host cells repair the damaged tissue.
PRODUCTION FACILITY
Tetratherix has established its own production faciltiy in Sydney, Alexandria. The company’s clean room production facility is fully equipped to manufacture sterile medical device in commercial scales. The infrastructure and the associated quality management system are ISO13485:2016 certified. The company’s in-house production facility is of a great importance for quality control, protection of technology know-hows, product development and production scalability. In addition, the company’s certified production capability facilitates efficient development and corporate partnership.
CLINICAL USE
TetraMatrix has been assessed in two clinical trials. The company has completed its first in-human trial in Perth, Australia and a pivotal trial is underway. The pilot trial involved the use of TetraMatrix for socket preservation, post tooth extraction. In all patients, the device was successfully administered and there was no need for membrane closure or micro-suturing at the extraction site. In follow-up visits, wound closure was noted at seven days post-extraction and there was no sign of infection or inflammation. Three months post-operation, tissue biopsies were collected for histochemical analysis; the results showed that TetraMatrix was fully resorbed and there were no sign pathological abnormalities. In addition, active bone remodelling was also noted at the site.
%
Useability
Easily injectable, instant gelation,
and no device malfunctions
%
Safety
No infection, inflammation
or pain reported
%
Wound Healing
Wound closure noted
at 7 days post-extraction
%
Bone Activity
Active bone remodelling
in all collected tissue samples
TECHNOLOGY
Polymer and peptide bonding
At a molecular level, TetraMatrix is a water based hydrogel comprising of a proprietary patented smart polymer and peptide which are chemically bound to form a uniform structure. Upon injection to the body, TetraMatrix forms an elastic scaffold. The mechanical properties, adhesivity and the resorption rate of TetraMatrix are modifiable to address different clinical indications.
Smart polymer
The smart polymer, denoted as PNPHO, was developed and patented by Tetratherix. PNPHO consists of four main building blocks each monomer is required to impart the unique characteristics of the technology;
- N-isopropylacrylamide to impart temperature curing properties to the matrix
- N-acryloxysuccinimide, to be able to bond with peptides to impart the required structural stability to the hydrogel
- Polylactide/2-hydroxy methacrylate to be able to adjust the mechanical properties of the matrix
- Oligo (ethylene glycol) to form a water based matrix
Peptide
Amine groups of peptides are chemically bound to the succinimide ester units of PNPHO, this process is termed crosslinking. The resorption rate of the final product can be tuned by the degree of crosslinking between PNPHO and a peptide. This allows the formulation of Tetratherix hydrogels with varying physical properties for different clinical applications.
PLATFORMS
TetraMatrix technology is used to develop pipeline products for multiple clinical indications.
Orthopaedics
TetraGlue is an injectable elastic scaffold which is easily applied to bone defects. The scaffold is inherently angiogeniconductive and supports vascular ingrowth. TetraGlue can be used as a carrier for osteoinductive compounds or as a stand-alone product.
Dental
TetraMax is a ready to use, injectable scaffold that is applied immediately after tooth extraction to facilitate wound healing in both soft and hard tissue. Unlike other bone substitutes, TetraMax is delivered to the socket as a liquid to stabilise the blood clot without the need for physical containment
Plastic and Reconstructive Surgery
TetraDerm is injectable ad form a sytethic extracellular matrix to support soft tissue regeneration. Results confirmed that wounds treated with Tetramatrix showed greater survival rate, enhanced neovascularisation and reduced inflammatory response compared to the gold standard.
TEAM
NEWS AND MEDIA
Series A Financing Completed
On 16 March 2020 Trimph closed a $5m Series A funding round. Ryder Innovation Fund is an early stage venture capital limited partnership specialising in medtech and tech opportunities. The Ryder Innovation Fund committed to fund the entire Series A raising of $5m,...
The New Innovators
Since its incorporation in August 2015, Trimph has secured more than $5.2 million in both private and public source. Their sterile facility is located in the Sydney suburb of Alexandria and is a key strategic asset for IP protection, quality control and early access to the Australian market.
Trimph – Alleviating the physical and systemic burdens of oral surgeries
In Australia there are almost 300,000 oral and maxillofacial surgeries a year, this is in addition to more than 60,000 hospital visits attributed to post-oral surgery complications. Trimph was founded in August 2015 by Dr Ali Fathi and Terence Abrams with the mission of alleviating the physical and systemic burdens caused by oral and maxillofacial surgeries.
Biotech startup Trimph has developed a “glue” intended to help regenerate bone tissue
By quickly healing the damaged tissue, Trimph is ultimately intended to reduce the pain and discomfort felt after a tooth has been extracted, an “inherently traumatic procedure”, and reduce the need for a secondary operation used to tend to complications resulting from the initial extraction.
This Australian biotech startup has produced a world-first bone “glue” and secured $3.4 million in funding
Australian biotech, Trimph, has successfully completed a first-in-human trial of its proprietary bone “glue”, TrimphDent, the only bone graft substitute in the world to be applied in liquid form, halving the time of patient recovery, and requiring no specialised preparation or additional surgical expertise.
CONTACT US
For more information or product for research purposes, please contact us.





DR ALI FATHI
Directror | Co-founder


TERENCE ABRAMS
Director | Co-founder


WILL KNOX
Director


DAVID BOTTOMLEY
Director


JEFF REID
Director


PROFESSOR DAVID CURROW
Clinical Advisor


DR DAX CALDER
Clinical Director


ROB MCINNES
Transactions Advisor


AOIFA BROGAN
Regulatory Advisor
